Report on pre-clinical QC survey

Download Report_COSTWG3Questionnaire.pdf

Publication abstract from joint COST centres

Download Divoli paper.pdf

Hindorf Poster survey & QC

Download hindorf_QC_COST_Nantes2009.pdf

Mission statement

Working Group 3 – Dosimetry and radiobiology Working group 3 will address fundamental issues and also support the other working groups of the COST action. The essential hypothesis of the WG is that individualised dosimetry-based treatments, taking radiobiological parameters into consideration, will result in significantly improved outcomes. There are several broad areas with which the group will be concerned. These will include Macroscopic dosimetry in clinical practice. As response to radionuclide therapy is dependent on absorbed dose, it is imperative that inter- and intra-patient variations in uptake and retention are recorded. The group will formulate protocols for data collection and processing that will be passed to participating centres and will provide support for these endeavours. Dosimetry for pre-clinical studies. Dosimetry at this scale is crucial to the understanding of the behaviour of new targeting agents. Pre-clinical dosimetry models for cell survival studies as well as in small animal research should be developed. These will include ideal timing schedules for data collection as well as definitions of common end-points for radiation effects. Radiobiological considerations for TRT. Accurate calculation of absorbed doses will facilitate radiobiological investigations of TRT including the effects of exponential decay, dose rate, LET and cellular binding site of the carrier on the linear quadratic model parameters (alpha/beta) and sub-lethal damage repair half-life. A further area to explore will be the possibility of combining radionuclide ‘cocktails’ or radionuclides with chemotherapy agents. The group will also endeavour to keep the management committee informed of current progress in internal dosimetry. Whilst this COST action is essentially funded for networking, it is hoped that it may provide a platform for scientific resourcing from the EU.